Team
Prof. Luca Casettari (PI) – Università of Urbino Carlo Bo
Dr. Mattia Tiboni
Dr. Beatrice Sabbatini
Prof. Dritan Hasa – Università of Trieste 
Dr. Ilenia D’Abbrunzo
Prof. Cinzia Pagano – Università of Perugia 
Dr. Anna Imbriano
Dr. Maria Mendico
Dr. Angela Abruzzo – Università of Bologna 
Dr. Giulia Bondi
Project
The development of age-appropriate and personalized formulations is still a necessity. Antibiotic medicines present a series of significant drawbacks due to the lack of specific studies in the different stages of the development of new oral dosage forms. Indeed, when it comes to therapeutic treatments it is nowadays widely accepted that the pediatric population has different needs from adults.
This project will explore and combine innovative strategies to obtain suitable oral antibiotic formulations, specifically designed for various pediatric age groups, through the advancement of new approaches for personalized medicine.
The goal is improving safety, efficacy, and acceptability, thus fulfilling specific pharmaceutical requirements such as bioavailability, dose uniformity, ease and safe administration.
p3Diatrics will impact current clinical scenarios by providing personalized therapies that, combined with an innovative approach from the materials science and formulation technology fields, represent an important step forward for the improvement of pharmacological compliance in pediatric antibiotic treatments.
Scientific Publications
Imbriano A., Fratini C., Bondi G., D’Abbrunzo I., Bertoni S., Tiboni M., Abruzzo A., Hasa D., Pagano C.* and Casettari L.
3D-printed chewable gummy tablets: a new tool for oral amoxicillin administration in paediatric population
International Journal of Pharmaceutics – Volume 677, 30 May 2025, – (IF 2023 = 5.3 – Q1)
Conference proceedings
- Fratini C. et al., 3D Bioprinting of amoxicillin-loaded hydrogels targeting paediatrics: a feasibility study.
CRS meeting and conference, Bologna, July 2024. - Bonafè S. et al., Design and characterization of child-friendly chewable-gummy tablets for amoxicillin administration.
CRS Italy Local Chapter, Workshop 2025, Bari 15 – 17 May - Abruzzo A. et al., Bilayered buccal films for azithromycin administration in children: preliminary studies.
5th European Conference on Pharmaceutics, Porto (Protugal) 24-25 March 2025 -
Bondi G. et al., Design of bilayered buccal films for azithromycin administration in pediatric population.
EPTRI Scientific Meeting 2025, Bologna 13-15 March 2025
Industrial interest
