Biopolymers functionalization

Derivatization of the chitosan polysaccharide.
FITC-g-chitosan, PEGylated chitosan, NAC-g-chitosan, gallic acid-g-chitosan.

 

Systems based on bioadhesive polymers for the delivery of local and systemic drugs

 

Biodegradable block polyesters synthesis

Custom diblock and triblock copolymers synthesis, with FT-IR, NMR, DSC and GPC characterizations.
(e.g. mPEG-PLA, mPEG-PLGA, mPEG-PCL and PLA-PEG-PLA, PLGA-PEG-PLGA, PCL-PEG-PCL).

 

Formulation and characterization of polymeric drug delivery systems.

Nano and microparticles formulations.
Rheological properties of thermogel systems.
Thermo-mechanical properties analyses (e.g. DSC and DMA).

 

Tabletting and Dissolution test.

Tablet formulations and characterizations.
Drug release studies of solid oral dosage forms (e.g. tablets and capsules).

 

Biodegradable polymeric scaffolds for tissue engineering

PEGylated biodegradable polyester like poly-lactide and poly(lactide-co-glycolide) were employed to perform scaffold for tissue engineering application. We are studying how the presence of these copolymers influenced the structural properties (e.g. porosity, swelling and mechanical behaviour) of polysaccharide scaffolds such as chitosan, dextran and alginate.